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View more on Pseudoephedrine Regulations View more about our active ingredients. The procedure may vary state by state, but generally to purchase a product containing the ingredient pseudoephedrine at a store with a pharmacy, you will need to do the following:. Only the products below are found at the pharmacy counter. They may recommend safer alternatives to help alleviate nasal congestion if required.

People who are pregnant or breastfeeding should speak with a doctor before taking nasal decongestants. According to an older review from , exposure to nasal decongestants during the first trimester may cause developmental defects in the growing fetus.

In this small study of eight breastfeeding women, a single dose of pseudoephedrine reduced milk production. The following people should not take nasal decongestants unless their doctor confirms it is safe for them to do so:. If a doctor determines that these decongestants are not safe, they may recommend other treatments to help relieve nasal congestion.

Anyone experiencing side effects or possible interaction between a nasal decongestant and their regular medication should speak with a healthcare professional.

Pseudoephedrine and phenylephrine are medications that can help alleviate nasal congestion. These drugs work by constricting blood vessels within the nose and sinuses, which allow people to breathe more easily. Individuals can find phenylephrine in various over-the-counter medications for cold, flu, and allergy symptoms. The sale of products containing pseudoephedrine is more restricted and varies from location to location.

Certain people need to speak with a doctor before they consider taking decongestants. This includes those taking existing medications, individuals with underlying health conditions, and those who are pregnant or breastfeeding. What are the best nasal decongestants for different ages? Read on to discover the best nasal decongestants by age and current research. Sinus congestion occurs when fluid becomes trapped in the sinuses. Home remedies including hydration, steam inhalation, and using eucalyptus oil….

Toddler congestion may be alleviated with home remedies. Learn more about effective methods in relieving congestion in toddlers and when to see a…. Sinus pressure can be a symptom of infection or allergies. While medication can help, some home remedies can also relieve the pressure. Learn more…. Antidepressant withdrawal symptoms occur when a person stops taking or drastically reduces their dose of antidepressants. Learn more in this article. Pseudoephedrine vs. What are they? Antihistamines, for instance, will slow the production of mucus and may augment the effects of nasal decongestants.

Phenylephrine in its oral, over-the-counter form does not require a prescription. It is typically not covered by Medicare or other commercial insurance plans. Pseudoephedrine, although restricted to purchase at a pharmacy, is also an OTC drug. If your doctor writes a prescription for pseudoephedrine, you will be able to obtain the quantity they prescribe even if it is higher than the state limit for over-the-counter purchases.

Pseudoephedrine is typically not covered by Medicare or other commercial insurance plans, though a select few may if a prescription is written. Get the SingleCare prescription discount card. Phenylephrine and pseudoephedrine are both adrenergic agonists and have some of the same side effects, though their difference in affinity for alpha- and beta-adrenergic receptors are responsible for some differences. Phenylephrine and pseudoephedrine are known to cause anxiety, dizziness, headache, insomnia, nervousness, and restlessness.

In addition, pseudoephedrine has been documented to cause tachycardia, palpitations, arrhythmia, blurred vision, and anorexia. It is difficult to define how frequently these side effects can occur.

Patients with high blood pressure or other known cardiac conditions should not use pseudoephedrine without guidance from their physician. The following table is not intended to be a complete list of side effects. You should consult a pharmacist or other healthcare professional for a complete list.

Source: DailyMed phenylephrine DailyMed pseudoephedrine. Phenylephrine and pseudoephedrine have a very similar drug interaction profile due to their adrenergic effects on the alpha and beta receptors. Alpha-blockers, such as tamsulosin, may diminish the vasoconstrictive properties of both decongestants making them less effective. MAO inhibitors, such as selegiline, and ergot derivatives, such as bromocriptine, may enhance the hypertensive effects of the decongestants.

This would be concerning in someone with pre-existing hypertension who may be considering decongestant use. The combination of phenylephrine or pseudoephedrine with either MAO inhibitors or ergot derivatives is contraindicated. The following list is not meant to be a complete list of all potential drug interactions.

Please consult your pharmacist or physician for a complete list and more information. Phenylephrine and pseudoephedrine are available without a prescription and are generally considered to be safe drugs. Due to their effects on the cardiac system, patients with high blood pressure and heart disease should not use these drugs without explicit consent from their physician. Health Conditions Discover Plan Connect. Pseudoephedrine vs. Pseudoephedrine and phenylephrine side by side.

Sudafed Sudafed PE Is a generic version available? Special requirements. Side effects. Drug interactions. Use with other medical conditions. Pregnancy and breastfeeding. Talk with your doctor. Read this next. Is It Allergies or a Cold? Medically reviewed by Judith Marcin, M. Medically reviewed by Natalie Olsen, R.

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